When gorgeous model Ai Shindo finds herself stalked by mysterious men, she comes to Ryo and his crew for protection. While he tries to hunt down the potential assassins (and maybe score a little nookie in the process), he ends up catching wind of a superweapon shipment landing in Shinjuku very soon. Could the two be connected? And with City Hunter on the case, will Tokyo survive the night?!

When video creator Angie knocks on the door of the City Hunter detective agency looking for a missing cat, Ryo Saeba and Kaori Makimura think they have a simple case on their hands. But an attempt on Angie's life changes the game, leaving Ryo in the crosshairs of mysterious assassins on the trail of Angel Dust, a military technology capable of creating super soldiers. Under the watchful eye of his adoptive father Kaibara, Ryo will have to deal with a past he has tried to escape for too long.