After a help signal from a research vessel makes it back to Earth, the U.S. Space Force sends a rescue ship to Pandora, a moon of Saturn. But when they try to land, they discover Pandora is inhabited by a highly evolved humanoid species.

Decades after humanity's first contact with Pandora, a new expedition returns to harvest what's left of the planet's resources-only to discover that the alien species is preparing to strike back against Earth.